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Diabetes and the effect of intermittent fasting on it

 

 

 

 

 

 

 

 

Type 2 diabetes (DM) is a common metabolic disorder characterized by hyperplasia caused by various factors including poor insulin secretion, insulin resistance, low use of glucose, excessive liver glucose production, and low -grade physical inflammation. According to the Center for Disease Control

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Diabetes affects 34.2 million people in the United States (10.5 % of the total population). it is known that DiabetesResponsible for the development of multiple long -term complications, which contribute to the disease and its deaths. For example, diabetes is the main cause of kidney failure, new blindness, and amputation of non -satisfactory lower extremities.

Diabetes complications can be either angical or non -vascular nature. The complications of the blood vessels include retinopathy, yellow spot edema, monouctural and multiple nerves, involuntary imbalance, kidney disease, coronary heart diseases, peripheral vascular diseases, and stroke.

Non -vascular complications include problems in the digestive system (stomach scratching), changes in skin color, increased risk of infection, eye lens, blue, gum disease, and hearing loss.

The target is currently centered on type 2 diabetes treatment about preventing or delaying complications and maintaining the quality of the patient’s life while it is recommended that type 2 diabetics participate in lifestyle changes

Including increased physical activity, weight loss and medical nutrition treatment, the majority of patients need to use medications to achieve control over their blood glucose levels.

Although it has been described Diabetes Type 2 well, it is an insulin -resistant disease

However, a large amount of medical treatments that doctors use depends on the hypothesis of giving the patient more insulin.

For example, drugs such as SULFONYLURES, anti-1, DPP-4, and various insulin inhibitors work

Either by increasing the internal production of insulin or increasing the amount of external insulin.

While this works to reduce high blood sugar in these patients

The idea of ​​treating insulin resistance disease by increasing insulin may have opposite results

Which leads to the need to take increasing amounts of medications over a long period of time.

A review was made to look at the possibility of using intermittent fasting as a non -medical option to treat type 2 diabetes by improving insulin sensitivity.

When thinking about the therapeutic role of intermittent fasting in diabetics, there are three hormones that are likely to play an important role. These include insulin, as well as Adipokines Leptin and Adiponectin.

 

 

 

Intermittent fasting, weight loss, and appetite control

Obesity is known to be a major risk factor for developing type 2 diabetes 2 DM. There are a number of mechanisms that are believed to contribute to developing insulin resistance in obesity patients. These include, but not limited to, chronic systemic inflammation and deposition of fat outside the womb. Violent fatty tissues are known to act as an endocrine and endocrine system through the secretion of anchibokin. These antibolicins are either causing infections lead to low -level chronic inflammation, such as leptin, or anti -inflammatory such as an adibonctin.

Leptin is known to play a role in regulating body weight by sending signals to the brain to suppress eating and increase energy spending.

It is possible that the inflammatory effects of the bibli are due to its role in the production of IL-6

Which stimulates the synthesis of the interactive protein C in the liver in addition to the regulation of the pro-inflammatory TNF-Aalpha compound.

Interestingly, patients with higher levels of body mass and insulin resistance have an increase in leptin levels

This may indicate that patients with obesity and insulin resistance are also developing leptin resistance.

On the contrary, it is known that adiponctin has anti -diabetes and anti -inflammatory effects.

Adebonctin works on different receptors that lead to an increase in the muscles of the skeleton and oxidation of fatty acids in the liver

And reduce the formation of sugar in the liver, and increase the absorption of glucose.

It also exercises anti-inflammatory effects through direct action on inflammatory cells, NF-KB work, and interactions with Tnfalpha. Adiponectin levels decrease with the accumulation of visceral fat.

A review with the aim of determining the levels of leptin and literature in patients with metabolic syndrome. They found that in patients with metabolic syndrome, which includes obesity and insulin resistance

It seems that the imbalance in the levels of leptin and adibonctin plays a role in the metaphorical change that increases the risk of developing type 2 diabetes.

It is interesting that many studies have shown that intermittent fasting, even if fat is not lost

It may lead to lower levels of leptin and the increase in adiponicin, which improves insulin resistance.

Reducing calories either by this diet alone or diet along with exercise

To improve insulin sensitivity and reduce beta cell allergy in individuals with weight gain and tolerate glucose.

Intermittent fasting has shown promising results in improving metabolic risk factors, body formation, and weight loss among individuals with obesity.

It has been proven that these useful effects are partially due to the shift while fasting from the use of glucose to fatty acids and ketones as a favorite fuel source of the body.

During this transformation, the body begins to transform from creating and storing fats to mobilizing fats in the form of ketogenic bodies and free fatty acids. This shift is highlighted by the source of fuel, or metabolic reinforcing, as a possible mechanism for many beneficial effects of intermittent fasting.

Finally, it has been proven that intermittent fasting reduces obesity, especially visceral fats and stem fats

This is largely due to moderate energy deficiency. Through this decrease in obesity. Patients may experience improvements in the levels and sensitivity of leptin / adiponctin

It improves appetite control and low levels of chronic inflammation and thus improve many risk factors for diabetes

Intermittent fasting and insulin sensitivity

Insulin plays an important role in glucose balance because of its effect in promoting storage and use of glucose. However, the effects of insulin are not limited to glucose balance. Insulin also plays a role in stimulating the synthesis of DNA, the synthesis of RNA, cell growth and distinction, amino acid flow, protein creation, discharge of protein, and most importantly, stimulate fat formation and discoloration of fat decomposition.

It is the development of insulin resistance, which is defined as the necessity of increasing the spreading insulin